Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
USERS' SCORE
Good
Based on 18 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Organic Turmeric BlendOrganic Turmeric Root Extract standardized to 95% curcuminoids, Organic Fermented Turmeric Root (blend yielding 100 mg curcuminoids)
553 mg
+
Organic Fermented Ginger Root
50 mg
+
Organic Black Pepper Fruit Extract
7 mg
+
Probiotic Blend Bifidobacterium lactis Bl-04Lactobacillus acidophilus La-14
4 mg
+
Top Medical Research Studies
9
In a recent clinical trial, we explored the effectiveness of Curcuma zedoaria Rosc., commonly known as turmeric, in treating non-alcoholic fatty liver disease (NAFLD). This condition is alarmingly widespread, affecting a significant portion of the global population. Over the course of 60 days, we compared turmeric with vitamin E, a standard treatment, to see which had better results.
Our study involved 68 patients with mild to moderate NAFLD, who were divided into two groups. One group received turmeric in capsule form, while the other took vitamin E. We looked at various outcomes, including improvements in liver function, symptoms like digestive issues and malaise, and ultrasound assessments of liver size.
The findings were compelling. We observed that turmeric outperformed vitamin E in alleviating subjective symptoms, such as discomfort in the upper right abdomen, and issues with appetite and digestion. Notably, there were no significant adverse effects reported with turmeric, making it a promising alternative for managing NAFLD.
Overall, our research highlights turmeric as a viable option for those seeking treatment for liver disease, offering benefits that may surpass those of conventional therapies.
Our study involved 68 patients with mild to moderate NAFLD, who were divided into two groups. One group received turmeric in capsule form, while the other took vitamin E. We looked at various outcomes, including improvements in liver function, symptoms like digestive issues and malaise, and ultrasound assessments of liver size.
The findings were compelling. We observed that turmeric outperformed vitamin E in alleviating subjective symptoms, such as discomfort in the upper right abdomen, and issues with appetite and digestion. Notably, there were no significant adverse effects reported with turmeric, making it a promising alternative for managing NAFLD.
Overall, our research highlights turmeric as a viable option for those seeking treatment for liver disease, offering benefits that may surpass those of conventional therapies.
Read More
9
We explored the effects of phytosomal curcumin, a derivative of turmeric, on various physical health indicators in individuals with nonalcoholic fatty liver disease (NAFLD). This analysis sifted through multiple studies, particularly randomized controlled trials, to gauge how effective turmeric extracts might be in managing this condition.
The findings revealed that curcumin could significantly reduce body mass index (BMI), body fat percentage, weight, and waist circumference in participants compared to those who received a placebo. For instance, the average decrease in BMI was notable, with a mean difference of -0.72. These positive impacts suggest that incorporating turmeric can be beneficial for those struggling with weight-related challenges due to NAFLD.
However, curcumin did not show any significant effect on hip circumference or the waist-to-hip ratio, indicating that while there are benefits, not every measure of body composition will respond to treatment. Overall, we observed that phytosomal curcumin stands out as a promising ally in the fight against the complications associated with nonalcoholic fatty liver disease, primarily by improving key anthropometric indices.
The findings revealed that curcumin could significantly reduce body mass index (BMI), body fat percentage, weight, and waist circumference in participants compared to those who received a placebo. For instance, the average decrease in BMI was notable, with a mean difference of -0.72. These positive impacts suggest that incorporating turmeric can be beneficial for those struggling with weight-related challenges due to NAFLD.
However, curcumin did not show any significant effect on hip circumference or the waist-to-hip ratio, indicating that while there are benefits, not every measure of body composition will respond to treatment. Overall, we observed that phytosomal curcumin stands out as a promising ally in the fight against the complications associated with nonalcoholic fatty liver disease, primarily by improving key anthropometric indices.
Read More
Our analysis looked into how curcumin, derived from turmeric, might help those suffering from nonalcoholic fatty liver disease (NAFLD). We reviewed various randomized clinical trials, gathering data from multiple studies to assess its effects on liver enzymes, particularly alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP).
After examining 14 studies, we found promising results for ALT and AST, with curcumin treatment leading to significant reductions in their levels. Specifically, ALT decreased by an average of about 8.72 units, while AST dropped by around 6.35 units. This indicates that curcumin supplementation might indeed benefit liver health by lowering these critical enzyme levels.
On the other hand, when it came to ALP, the results weren't as clear-cut. Our pooled analysis showed no significant effect on ALP levels overall. However, further exploration revealed that patients who took curcumin for longer periods saw some benefits in their ALP readings.
In conclusion, our findings suggest that curcumin could play a useful role in managing liver health in individuals with NAFLD, particularly in reducing certain liver enzymes. However, we believe further studies are essential to fully understand these effects and offer clearer guidelines for supplementation.
After examining 14 studies, we found promising results for ALT and AST, with curcumin treatment leading to significant reductions in their levels. Specifically, ALT decreased by an average of about 8.72 units, while AST dropped by around 6.35 units. This indicates that curcumin supplementation might indeed benefit liver health by lowering these critical enzyme levels.
On the other hand, when it came to ALP, the results weren't as clear-cut. Our pooled analysis showed no significant effect on ALP levels overall. However, further exploration revealed that patients who took curcumin for longer periods saw some benefits in their ALP readings.
In conclusion, our findings suggest that curcumin could play a useful role in managing liver health in individuals with NAFLD, particularly in reducing certain liver enzymes. However, we believe further studies are essential to fully understand these effects and offer clearer guidelines for supplementation.
Read More
Most Useful Reviews
9
Pelvic pain relief
7 people found this helpful
It works! I've been struggling with lower stomach discomfort and pains linked to liver disease caused by uterine fibroids. Typically, I drink green tea for relief, but I've been too busy recently. This product provided almost immediate relief from my pelvic pain. I'm hoping it also reduces my fibroid size since turmeric is known for its anti-inflammatory properties. It has worked well for me, but I recommend consulting a doctor before using it.
Read More
9
Liver health improvement
3 people found this helpful
I took this to cleanse my liver and pancreas as per my doctor's advice. Pains and unpleasant sensations disappeared, and I experienced noticeable improvements in my liver health, including the elimination of toxins and bad breath. I'm very satisfied with these results.
Read More
9
Blood thinning effect
3 people found this helpful
After six months of taking curcumin for my dad's severe varicose veins related to liver disease, he avoided surgery. During COVID-19, I started using it for blood thinning. Now, my blood is so thin that stopping a cut has become challenging. This product is effective and essential for our family’s health, aiding in various ailments.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
- All Researches
9.5
We explored the use of curcumin, a compound found in turmeric, in treating acute liver injury (ALI). To enhance curcumin's effectiveness, we created a specialized delivery system using human serum albumin (HSA) that releases curcumin in response to reactive oxygen species (ROS), which are often elevated during inflammation. This system was then cloaked with macrophage membranes to improve targeting to inflamed liver tissues.
Our results showed that this innovative approach allowed the curcumin to be effectively delivered to the injured liver, where it significantly reduced ROS levels and the production of pro-inflammatory cytokines. This suggests that curcumin can help alleviate inflammation during ALI by shifting the balance of immune responses.
We found that the delivery system helped protect liver cells from oxidative stress and promoted a shift in the immune response, which is a vital part of recovery from liver injury. Overall, we observed promising outcomes that position this curcumin delivery method as a potential therapy for managing acute liver injury.
Our results showed that this innovative approach allowed the curcumin to be effectively delivered to the injured liver, where it significantly reduced ROS levels and the production of pro-inflammatory cytokines. This suggests that curcumin can help alleviate inflammation during ALI by shifting the balance of immune responses.
We found that the delivery system helped protect liver cells from oxidative stress and promoted a shift in the immune response, which is a vital part of recovery from liver injury. Overall, we observed promising outcomes that position this curcumin delivery method as a potential therapy for managing acute liver injury.
Read More
9
We explored the effects of phytosomal curcumin, a derivative of turmeric, on various physical health indicators in individuals with nonalcoholic fatty liver disease (NAFLD). This analysis sifted through multiple studies, particularly randomized controlled trials, to gauge how effective turmeric extracts might be in managing this condition.
The findings revealed that curcumin could significantly reduce body mass index (BMI), body fat percentage, weight, and waist circumference in participants compared to those who received a placebo. For instance, the average decrease in BMI was notable, with a mean difference of -0.72. These positive impacts suggest that incorporating turmeric can be beneficial for those struggling with weight-related challenges due to NAFLD.
However, curcumin did not show any significant effect on hip circumference or the waist-to-hip ratio, indicating that while there are benefits, not every measure of body composition will respond to treatment. Overall, we observed that phytosomal curcumin stands out as a promising ally in the fight against the complications associated with nonalcoholic fatty liver disease, primarily by improving key anthropometric indices.
The findings revealed that curcumin could significantly reduce body mass index (BMI), body fat percentage, weight, and waist circumference in participants compared to those who received a placebo. For instance, the average decrease in BMI was notable, with a mean difference of -0.72. These positive impacts suggest that incorporating turmeric can be beneficial for those struggling with weight-related challenges due to NAFLD.
However, curcumin did not show any significant effect on hip circumference or the waist-to-hip ratio, indicating that while there are benefits, not every measure of body composition will respond to treatment. Overall, we observed that phytosomal curcumin stands out as a promising ally in the fight against the complications associated with nonalcoholic fatty liver disease, primarily by improving key anthropometric indices.
Read More
9
We explored the effects of Tetrahydrocurcumin (THC), a compound derived from turmeric, on liver disease, specifically focusing on metabolic dysfunction-associated steatohepatitis (MASH). The study involved C57BL/6 mice that were subjected to a methionine-choline-deficient diet for eight weeks to induce MASH. We administered THC to one group of mice while another group received obeticholic acid as a positive control.
After treatment, we observed several promising outcomes. THC significantly reduced oxidative stress and fat accumulation in liver cells, lessened liver injury, and improved overall liver health in the mice. It also corrected 34 different lipid imbalances brought on by the diet, enhancing the diversity and abundance of beneficial gut bacteria while lowering harmful strains linked to obesity.
Additionally, bile acid analysis showed THC decreased the levels of certain toxic bile acids in the serum that can harm the liver. Importantly, THC also influenced gene expression related to fat production and bile acid secretion, indicating a multifaceted approach to combating liver issues. Overall, this research suggests that THC may be a valuable compound in promoting liver health and offers insights for future treatments targeting MASH.
After treatment, we observed several promising outcomes. THC significantly reduced oxidative stress and fat accumulation in liver cells, lessened liver injury, and improved overall liver health in the mice. It also corrected 34 different lipid imbalances brought on by the diet, enhancing the diversity and abundance of beneficial gut bacteria while lowering harmful strains linked to obesity.
Additionally, bile acid analysis showed THC decreased the levels of certain toxic bile acids in the serum that can harm the liver. Importantly, THC also influenced gene expression related to fat production and bile acid secretion, indicating a multifaceted approach to combating liver issues. Overall, this research suggests that THC may be a valuable compound in promoting liver health and offers insights for future treatments targeting MASH.
Read More
9
In a recent clinical trial, we explored the effectiveness of Curcuma zedoaria Rosc., commonly known as turmeric, in treating non-alcoholic fatty liver disease (NAFLD). This condition is alarmingly widespread, affecting a significant portion of the global population. Over the course of 60 days, we compared turmeric with vitamin E, a standard treatment, to see which had better results.
Our study involved 68 patients with mild to moderate NAFLD, who were divided into two groups. One group received turmeric in capsule form, while the other took vitamin E. We looked at various outcomes, including improvements in liver function, symptoms like digestive issues and malaise, and ultrasound assessments of liver size.
The findings were compelling. We observed that turmeric outperformed vitamin E in alleviating subjective symptoms, such as discomfort in the upper right abdomen, and issues with appetite and digestion. Notably, there were no significant adverse effects reported with turmeric, making it a promising alternative for managing NAFLD.
Overall, our research highlights turmeric as a viable option for those seeking treatment for liver disease, offering benefits that may surpass those of conventional therapies.
Our study involved 68 patients with mild to moderate NAFLD, who were divided into two groups. One group received turmeric in capsule form, while the other took vitamin E. We looked at various outcomes, including improvements in liver function, symptoms like digestive issues and malaise, and ultrasound assessments of liver size.
The findings were compelling. We observed that turmeric outperformed vitamin E in alleviating subjective symptoms, such as discomfort in the upper right abdomen, and issues with appetite and digestion. Notably, there were no significant adverse effects reported with turmeric, making it a promising alternative for managing NAFLD.
Overall, our research highlights turmeric as a viable option for those seeking treatment for liver disease, offering benefits that may surpass those of conventional therapies.
Read More
9
We investigated a promising approach to tackle liver fibrosis, a serious condition linked to chronic liver diseases. Our focus was on curcumin, a compound found in turmeric, and its ability to be effectively delivered to the liver using innovative nanocarriers.
Our study utilized a specially designed delivery system that paired curcumin with a metal-based substance known as Cu-coordinated mesoporous polydopamine (CMP). This combination not only aimed to harness the antifibrotic properties of curcumin but also to address the buildup of harmful reactive oxygen species (ROS) that contribute to liver damage.
We found that the CMP carried curcumin efficiently while improving its antioxidant abilities, leading to better cellular uptake. Importantly, tests showed that this nanodrug significantly reduced the proliferation of liver cells that lead to fibrosis and effectively scavenged harmful ROS without harmful effects on healthy cells.
In vivo studies demonstrated that the combination of curcumin and CMP reduced collagen deposits, alleviating liver fibrosis while maintaining safety. This highlights the potential of using turmeric-derived curcumin in targeted treatments for liver diseases, paving the way for better therapeutic strategies.
Our study utilized a specially designed delivery system that paired curcumin with a metal-based substance known as Cu-coordinated mesoporous polydopamine (CMP). This combination not only aimed to harness the antifibrotic properties of curcumin but also to address the buildup of harmful reactive oxygen species (ROS) that contribute to liver damage.
We found that the CMP carried curcumin efficiently while improving its antioxidant abilities, leading to better cellular uptake. Importantly, tests showed that this nanodrug significantly reduced the proliferation of liver cells that lead to fibrosis and effectively scavenged harmful ROS without harmful effects on healthy cells.
In vivo studies demonstrated that the combination of curcumin and CMP reduced collagen deposits, alleviating liver fibrosis while maintaining safety. This highlights the potential of using turmeric-derived curcumin in targeted treatments for liver diseases, paving the way for better therapeutic strategies.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Pelvic pain relief
7 people found this helpful
It works! I've been struggling with lower stomach discomfort and pains linked to liver disease caused by uterine fibroids. Typically, I drink green tea for relief, but I've been too busy recently. This product provided almost immediate relief from my pelvic pain. I'm hoping it also reduces my fibroid size since turmeric is known for its anti-inflammatory properties. It has worked well for me, but I recommend consulting a doctor before using it.
Read More
9
Liver health improvement
3 people found this helpful
I took this to cleanse my liver and pancreas as per my doctor's advice. Pains and unpleasant sensations disappeared, and I experienced noticeable improvements in my liver health, including the elimination of toxins and bad breath. I'm very satisfied with these results.
Read More
9
Blood thinning effect
3 people found this helpful
After six months of taking curcumin for my dad's severe varicose veins related to liver disease, he avoided surgery. During COVID-19, I started using it for blood thinning. Now, my blood is so thin that stopping a cut has become challenging. This product is effective and essential for our family’s health, aiding in various ailments.
Read More
9
Memory enhancement
2 people found this helpful
Curcumin is a powerful antioxidant! I use it for various issues related to liver disease, including improving liver and biliary functions and reducing joint pain. The quality of this brand is outstanding, and I felt its effectiveness from the first dose. I highly recommend it!
Read More
9
Joint pain relief
2 people found this helpful
I liked this turmeric product for relieving inflammation in my joints due to liver disease. After a month, I began to feel better, with greater flexibility and reduced pain. My gallstones have also ceased to cause issues. I've ordered more for the next two months.
Read More
Frequently Asked Questions
9
Pelvic pain relief
7 people found this helpful
It works! I've been struggling with lower stomach discomfort and pains linked to liver disease caused by uterine fibroids. Typically, I drink green tea for relief, but I've been too busy recently. This product provided almost immediate relief from my pelvic pain. I'm hoping it also reduces my fibroid size since turmeric is known for its anti-inflammatory properties. It has worked well for me, but I recommend consulting a doctor before using it.
9
Liver health improvement
3 people found this helpful
I took this to cleanse my liver and pancreas as per my doctor's advice. Pains and unpleasant sensations disappeared, and I experienced noticeable improvements in my liver health, including the elimination of toxins and bad breath. I'm very satisfied with these results.
9
Joint pain relief
2 people found this helpful
I liked this turmeric product for relieving inflammation in my joints due to liver disease. After a month, I began to feel better, with greater flexibility and reduced pain. My gallstones have also ceased to cause issues. I've ordered more for the next two months.
7.5
Joint pain improvement
7 people found this helpful
Great quality! I took a supplement for sore joints due to my liver disease, as anti-inflammatory drugs are unsuitable for me. After three months of use, my toe joint no longer bothers me, my complexion has improved, and I haven’t needed my daily omeprazole for pain and heartburn for four months. I will continue taking it!
7.5
Gut health improvement
1 people found this helpful
I have Hashimoto’s disease and aim to reduce my antibodies naturally through diet and supplements. This product is excellent, and I trust it while noticing improvements in my gut health. Combined with a 100 billion probiotic from the same company, my constipation disappeared after 10 days. Highly recommend.
7.5
Inflammation reduction
4 people found this helpful
The best turmeric! My wife has taken this for several years due to her liver disease. While the pain isn’t entirely gone, it significantly reduces inflammation and helps maintain proper liver function while on heavy medications. Highly recommended!
9
Anti-inflammatory properties
1 people found this helpful
This is a superb remedy for colds and gastrointestinal issues due to its anti-inflammatory effects. It helps with bile and blood thinning, but caution is advisable if you have liver disease or take anticoagulants. One tablet daily is sufficient.
7.5
Joint and liver benefits
The quality of this supplement is excellent. I took it to improve my liver condition and joint health. It serves as a good antioxidant and alleviates inflammation, and I only need to take one dose per day.
8
We investigated how curcumin, a natural antioxidant found in turmeric, can help protect the liver from damage caused by alcohol consumption. In our study, we used HepG2 cells, which are a model for liver cells, and treated them with different concentrations of alcohol to mimic alcohol-related liver disease (ARLD).
We noticed that a high alcohol concentration led to decreased cell survival and an increase in harmful reactive oxygen species (ROS)—molecules that can cause oxidative stress in the liver. This oxidative stress not only damaged the cells but also resulted in cell death and mitochondrial dysfunction over time.
Curcumin nanofunctions showed promise; when we pre-treated the liver cells with these formulations, we observed an increase in cell viability and a reduction in ROS levels after just a few hours. This suggests that curcumin could play a role in mitigating the adverse effects of alcohol on liver health.
Our findings indicate that curcumin and its nanoformulations could be beneficial in reducing oxidative damage in liver disease, but further research is needed to explore this potential in more detail.
We noticed that a high alcohol concentration led to decreased cell survival and an increase in harmful reactive oxygen species (ROS)—molecules that can cause oxidative stress in the liver. This oxidative stress not only damaged the cells but also resulted in cell death and mitochondrial dysfunction over time.
Curcumin nanofunctions showed promise; when we pre-treated the liver cells with these formulations, we observed an increase in cell viability and a reduction in ROS levels after just a few hours. This suggests that curcumin could play a role in mitigating the adverse effects of alcohol on liver health.
Our findings indicate that curcumin and its nanoformulations could be beneficial in reducing oxidative damage in liver disease, but further research is needed to explore this potential in more detail.
Our analysis looked into how curcumin, derived from turmeric, might help those suffering from nonalcoholic fatty liver disease (NAFLD). We reviewed various randomized clinical trials, gathering data from multiple studies to assess its effects on liver enzymes, particularly alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP).
After examining 14 studies, we found promising results for ALT and AST, with curcumin treatment leading to significant reductions in their levels. Specifically, ALT decreased by an average of about 8.72 units, while AST dropped by around 6.35 units. This indicates that curcumin supplementation might indeed benefit liver health by lowering these critical enzyme levels.
On the other hand, when it came to ALP, the results weren't as clear-cut. Our pooled analysis showed no significant effect on ALP levels overall. However, further exploration revealed that patients who took curcumin for longer periods saw some benefits in their ALP readings.
In conclusion, our findings suggest that curcumin could play a useful role in managing liver health in individuals with NAFLD, particularly in reducing certain liver enzymes. However, we believe further studies are essential to fully understand these effects and offer clearer guidelines for supplementation.
After examining 14 studies, we found promising results for ALT and AST, with curcumin treatment leading to significant reductions in their levels. Specifically, ALT decreased by an average of about 8.72 units, while AST dropped by around 6.35 units. This indicates that curcumin supplementation might indeed benefit liver health by lowering these critical enzyme levels.
On the other hand, when it came to ALP, the results weren't as clear-cut. Our pooled analysis showed no significant effect on ALP levels overall. However, further exploration revealed that patients who took curcumin for longer periods saw some benefits in their ALP readings.
In conclusion, our findings suggest that curcumin could play a useful role in managing liver health in individuals with NAFLD, particularly in reducing certain liver enzymes. However, we believe further studies are essential to fully understand these effects and offer clearer guidelines for supplementation.
3
We examined how curcumin, a natural compound found in turmeric, influences the hepatitis B virus (HBV) in liver cells. The research focused on two different liver cell lines, HepG22.15 and Huh7, to determine whether curcumin has a positive effect on HBV replication.
Our findings revealed a strikingly different response between the two cell lines. In HepG22.15 cells, curcumin didn’t seem to affect the levels of viral DNA or some RNA forms, but it did lower specific antigen levels. In contrast, Huh7 cells responded to curcumin with a significant increase in HBV replication and higher levels of viral antigens and RNAs.
Additionally, we looked at how curcumin affected cellular processes. In Huh7 cells, we observed that curcumin triggered cell cycle changes, particularly causing an arrest at a specific phase, which might create an environment favorable for viral replication. However, no such changes occurred in HepG22.15 cells. Overall, this variability raises questions about the consistent effectiveness of curcumin for liver disease treatment, making its role somewhat controversial.
Our findings revealed a strikingly different response between the two cell lines. In HepG22.15 cells, curcumin didn’t seem to affect the levels of viral DNA or some RNA forms, but it did lower specific antigen levels. In contrast, Huh7 cells responded to curcumin with a significant increase in HBV replication and higher levels of viral antigens and RNAs.
Additionally, we looked at how curcumin affected cellular processes. In Huh7 cells, we observed that curcumin triggered cell cycle changes, particularly causing an arrest at a specific phase, which might create an environment favorable for viral replication. However, no such changes occurred in HepG22.15 cells. Overall, this variability raises questions about the consistent effectiveness of curcumin for liver disease treatment, making its role somewhat controversial.
8
We examined a body of research focused on the effects of turmeric, specifically its active component curcumin, on liver disease, particularly metabolic dysfunction-associated steatotic liver disease (MASLD). The analysis drew from numerous studies that included randomized controlled trials and systematic reviews covering the period from 2000 to 2023.
Our findings revealed that turmeric, through its active curcumin, has been one of the most studied bioactive substances in relation to liver health. Out of the total research, 25 studies were specifically dedicated to curcumin's effects. This suggests a significant interest in its potential benefits for those suffering from liver conditions.
However, we also noted substantial variation in how the studies measured their outcomes. Most commonly, researchers reported on aspects like liver health, body weight, and blood lipid levels, but there remains a crucial need for more uniformity and clarity in how results are interpreted. Despite promising trends, definitive conclusions on curcumin's effectiveness still require further investigation and synthesis of existing findings to establish clear clinical guidelines.
Overall, while there is a wealth of information suggesting turmeric may help, it is important to dive deeper into this research to confirm its benefits for liver disease and understand the nuances that come with it.
Our findings revealed that turmeric, through its active curcumin, has been one of the most studied bioactive substances in relation to liver health. Out of the total research, 25 studies were specifically dedicated to curcumin's effects. This suggests a significant interest in its potential benefits for those suffering from liver conditions.
However, we also noted substantial variation in how the studies measured their outcomes. Most commonly, researchers reported on aspects like liver health, body weight, and blood lipid levels, but there remains a crucial need for more uniformity and clarity in how results are interpreted. Despite promising trends, definitive conclusions on curcumin's effectiveness still require further investigation and synthesis of existing findings to establish clear clinical guidelines.
Overall, while there is a wealth of information suggesting turmeric may help, it is important to dive deeper into this research to confirm its benefits for liver disease and understand the nuances that come with it.
References
- Petagine L, Zariwala MG, Somavarapu S, Chan SHY, Kaya EA, et al. Oxidative stress in a cellular model of alcohol-related liver disease: protection using curcumin nanoformulations. Sci Rep. 2025;15:7752. doi:10.1038/s41598-025-91139-0
- Elizalde MM, Fuentes P, Chiappetta D, Flichman DM. Contrasting Effect of Curcumin on Hepatitis B Virus Replication According to the Hepatoma Cell Line. Pathogens. 2025;14. doi:10.3390/pathogens14020203
- Liu N, Li H. Influence of phytosomal curcumin on anthropometric indices for nonalcoholic fatty liver disease: A meta-analysis. Medicine (Baltimore). 2024;103:e40538. doi:10.1097/MD.0000000000040538
- Hamouda MAB, Saad AH, El-Saadany AAEAE, El Sharawey TMHA, Abdo W, et al. Trials for reducing the dangerous effect on poultry fed on aflatoxin contaminated ration using nano curcumin. BMC Vet Res. 2025;21:72. doi:10.1186/s12917-025-04519-z
- Hemati S, Mehrabinejad F, Elhaie M, Najafizade N. Curcumin Supplementation as a Preventive Strategy Against Tamoxifen-Induced Nonalcoholic Fatty Liver Disease in ER+ Breast Cancer Patients: A Triple-Blind Randomized Placebo-Controlled Trial. J Diet Suppl. 2025;22:274. doi:10.1080/19390211.2025.2465412
- Peng S, Meng M, Luo P, Liu J, Wang J, et al. Tetrahydrocurcumin Alleviates Metabolic Dysfunction-Associated Steatohepatitis in Mice by Regulating Serum Lipids, Bile Acids, and Gut Microbiota. Int J Mol Sci. 2025;26. doi:10.3390/ijms26030895
- Handu D, Stote K, Piemonte T. Evaluating Bioactive-Substance-Based Interventions for Adults with MASLD: Results from a Systematic Scoping Review. Nutrients. 2025;17. doi:10.3390/nu17030453
- Feng JN, Shao W, Yang L, Pang J, Ling W, et al. Hepatic fibroblast growth factor 21 is required for curcumin or resveratrol in exerting their metabolic beneficial effect in male mice. Nutr Diabetes. 2025;15:4. doi:10.1038/s41387-025-00363-0
- Ashraf A, Rather SA, Mehraj M. "Evaluation of Curcuma zedoaria Rosc. in the management of non-alcoholic fatty liver Disease: A Randomized, single blind, controlled trial". Arab J Gastroenterol. 2025;26:112. doi:10.1016/j.ajg.2025.01.004
- Liu X, Mu X, Wang Y, Liu Z, Li Y, et al. Metal-based mesoporous polydopamine with dual enzyme-like activity as biomimetic nanodrug for alleviating liver fibrosis. J Colloid Interface Sci. 2025;684:586. doi:10.1016/j.jcis.2025.01.081
- Ebrahimzadeh A, Ebrahimzadeh A, Fooladshekan S, Mohseni S, Mohtashamian A, et al. Therapeutic effects of curcumin supplementation on liver enzymes of nonalcoholic fatty liver disease patients: A systematic review and meta-analysis of randomized clinical trials. Food Sci Nutr. 2025;13:e4144. doi:10.1002/fsn3.4144
- Hu D, Huang Z, Li W, Shan L, Wu MY, et al. Macrophage Membrane-Cloaked ROS-Responsive Albumin Nanoplatforms for Targeted Delivery of Curcumin to Alleviate Acute Liver Injury. Mol Pharm. 2025;22:771. doi:10.1021/acs.molpharmaceut.4c00808
- Lee SO, Chu KB, Yoon KW, Heo SI, Song JH, et al. Combinatorial Treatment with Praziquantel and Curcumin Reduces Parasite Burden and Clonorchiasis-Associated Pathologies in Rats. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16121550
- Huang Q, An Z, Xin X, Gou X, Tian X, et al. The Effectiveness of Curcumin, Resveratrol, and Silymarin on MASLD: A Systematic Review and Meta-Analysis. Food Sci Nutr. 2024;12:10010. doi:10.1002/fsn3.4595
- Ranneh Y, Bedir AS, Abu-Elsaoud AM, Al Raish S. Polyphenol Intervention Ameliorates Non-Alcoholic Fatty Liver Disease: An Updated Comprehensive Systematic Review. Nutrients. 2024;16. doi:10.3390/nu16234150
- Wu Y, Guo F, Ma Y, Chai W, Li J, et al. Curcumin's Protective Role in Heatstroke-Induced Acute Liver Injury: Targeting Pyroptosis and Enhancing SIRT1 Expression. Glob Chall. 2024;8:2400178. doi:10.1002/gch2.202400178
